Been diagnosed on a molecular level; mutations in 14 different genes are known to date leading to causal defects in presynaptic nerve terminal, synaptic cleft, and postsynaptic apparatus. At last, all known mutations are estimated to cause approximately 50% of all clinically diagnosed cms. However, phenotypes may vary widely and symptoms can be unspecific, therefore cms are often missed and their prevalence may be underestimated. But, the exact diagnosis is extremely important to start early appropriate therapy to prevent life-threatening events and to improve the clinical course. Most patients are eligible for drug therapy with esterase inhibitors, 3, 4-diaminopyridine, ephedrine, fluoxetine or quinidine, but the effect of these drugs differs depending on the underlying genetic defect. Moreover, very little is known about the best treatment and care in these patients over a longer period of time. This article provides an overview of specific clinical symptoms, diagnostic work-up, and care including possible pharmacotherapy in case of cms. Thieme medical publishers 333 seventh avenue, new york, ny 10001, usa. viagra online Pmid: 22911480 [pubmed - in process] linkout - more resources full text sources georg thieme verlag stuttgart, new york ebsco ohiolink electronic journal center miscellaneous swets information services supplemental content save items add to favorites loading related citations in pubmed review therapeutic strategies in congenital myasthenic syndromes. [neurotherapeutics. 2008] review therapeutic strategies in congenital myasthenic syndromes. Schara u, lochmã¼ller h. Neurotherapeutics. where to buy viagra philippines 2008 oct; 5(4):542-7. buy generic viagra Review [congenital myasthenic syndromes: phenotypic expression and pathophysiological characterisation]. [rev neurol (paris). viagra or viagra or viagra 2004] review [congenital myasthenic syndromes: phenotypic expression and pathophysiological characterisation]. Andreux f, hanta㯠d, eymard b. Rev neurol (paris). 2004 feb; 160(2):163-76. Clinical and molecular genetic findings in colq-mutant congenital myasthenic syndromes. [brain. order viagra online 2008] clinical and molecular genetic findings in colq-mutant congenital myasthenic syndromes. Mihaylova v, mã¼ller js, vilchez jj, salih ma, kabiraj mm, d'amico a, bertini e, wã¶lfle j, schreiner f, kurlemann g, et al. Brain. where to buy viagra philippines 2008 mar; 131(pt 3):747-59. Epub 2008 jan 7. Review congenital myasthenic syndromes. [j clin neurosci. 2009] review congenital myasthenic syndromes. buy viagra cheap Nogajski jh, kiernan mc, ouvrier ra, andrews pi. J clin neurosci. 2009 jan; 16(1):1-11. Epub 2008 nov 18. Review congenital myasthenic syndrome: a brief review. [pediatr neurol. where to buy viagra philippines 2012] review congenital myasthenic syndrome: a brief review. Lorenzoni pj, scola rh, kay cs, werneck lc. viagra 100 wikipedia Pediatr neurol. 2012 mar; 46(3):141-8. See reviews... See all... Related information related citations calcu. cheap viagra overnight sweet-vibrations.com/tkj-generic-viagra-online-canada-cost-bk/

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